July 15, 2003
GLOBAL ACCESS TO CHEMNAVIGATOR'S iRESEARCH™ SYSTEM & LIBRARY PURCHASED BY ASTRAZENECA

Researchers gain access to data on over 10 million drug-like chemical samples

ChemNavigator today announced that AstraZeneca has successfully launched a new program providing its researchers, in major centers throughout the world, access to ChemNavigator's iResearch System and iResearch Library database of over 10 million chemical samples for drug discovery. Under the terms of the subscription agreement initiated earlier this year, AstraZeneca medicinal chemists will use the on-line iResearch System application to identify external chemistry samples to be used for early drug discovery research, and computational chemists at AstraZeneca will use an internal version of the iResearch Library for virtual screening and other computer-aided drug discovery projects. The iResearch System will also automatically alert AstraZeneca scientists when compounds that may be applicable to their particular project become available.

"AstraZeneca's world-wide license allows their researchers to identify and acquire drug-like chemical samples that are commercially available for a fraction of the cost of internal chemical synthesis," comments Scott Hutton, president and chief executive officer of ChemNavigator. "We look forward to working with AstraZeneca medicinal and computational chemists."

"The use of ChemNavigator's iResearch System and Library will considerably streamline our compound acquisition approach," commented Dr. Mike Cox, AstraZeneca's Director of Global Compound Management. "Our scientists will now have ready access to information in standardized format about current availability of millions of compounds of potential utility in AstraZeneca's drug discovery programs."

About the iResearch System and iResearch Library
The iResearch System and Library are part of a growing suite of products and services from ChemNavigator called ChemMatrix™. ChemMatrix based products enable researchers to perform more efficient drug discovery through chemical information analysis techniques called cheminformatics.

The iResearch System integrates the world's inventory of commercially accessible compounds with scientific information related to those compounds, providing the individual researcher with an efficient means of identifying and purchasing compounds from commercial suppliers, while "pushing" relevant scientific knowledge surrounding that area of chemistry to the researcher. The iResearch System contains over 10 million chemical structure records and is available to scientists around the world through secure Internet connections.

The iResearch Library is the most up-to-date compilation of commercially accessible drug-like compounds used for pharmaceutical research. The library currently tracks over 10 million chemical samples from sources around the world. Over 1 million records each month are processed including additions of new chemistry, reconfirmation of existing offerings, and removal of unavailable chemistry. The library may be licensed on CD/DVD ROM. Database licenses include access to regular updates, sample sourcing information, and ChemNavigator's optional Chemistry Procurement Service. Licensing the iResearch Library with the update service eliminates a pharmaceutical research organization's need to aggregate and maintain information about the constantly changing inventory of research compounds that are available from worldwide chemistry sources.

About ChemNavigator, Inc.
ChemNavigator is a privately held biotechnology company focused on drug discovery using our proprietary proteomics and cheminformatics technologies, called 3-DPL™ Map and ChemMatrix™. Our competitive advantage is our unique ability to identify and analyze, with unmatched speed, the biochemical relationships that exist between a potential drug compound and its entire drug target molecule. Our 3-DPL Map technology allows for more efficient and cost effective drug discovery by providing the ability to screen tens of millions of potential drugs in silico in order to rapidly identify compounds with a high likelihood of showing favorable activity. Our ChemMatrix technology is employed within products and services used by over 40 pharmaceutical and biotechnology companies to perform more cost effective new drug discovery.





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